To compare the intraocular pressure efficacy and safety of the DTFC given twice daily versus the LTFC given once every morning following a run-in period with timolol maleate given twice daily.

Inclusion Criteria:

• adults with primary open-angle or pigment-dispersion glaucoma, or ocular hypertension
• at baseline the intraocular pressure should be 20 to 32 mm Hg inclusive at 08:00 measurement (Visit 2) after dosing with timolol the evening before
• the intraocular pressure should be 32 mm Hg or less at all the time points in both eyes at Visit 2
• visual acuity should be 6/60 or better in the study eye(s)

Exclusion Criteria:

• any anticipated change in systemic hypotensive therapy during the trial
• use of any corticosteroids by any route for more than two weeks during the study
• contraindications to study medicines