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| Name | Class |
|---|---|
| St. Olavs Hospital | OTHER |
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Endurance training has a documented effect on hypertension. However, only low to moderate training intensity has so far been studied. High aerobic intensity should, from physiological considerations, prove more effective in also reducing high blood pressure. The present study is a randomised comparison of high versus moderate intensity versus training in groups, and general advice on 24 hour blood pressure in hypertensives. The training period is 12 weeks, with follow-up after 1 year. Maximum oxygen uptake, quality of life, left ventricular function and blood vessel reactivity are also measured.
Endurance training has documented effect on blood pressure in hypertension. However, only low to moderate training intensity has so far been studied. Higher aerobic intensity based on individual measurements of maximum oxygen uptake is more efficient in increasing oxygen uptake, and might prove more effective in lowering blood pressure. Group training, on the other hand is not individualised, but less personnel required and may prove more cost effective. Endurance training is shown to improve both systolic and diastolic left ventricular function, as well as endothelial function. Both can be measured non-invasively by ultrasound.
The study is an open, randomised study with four arms, comparing:
Training effect is measured by Max. Oxygen uptake, blood pressure by continuous 24 hour ambulatory measurement, Left ventricular function by echo Doppler and endothelial function by flow mediated vasodilation by ultrasound.
The effect of exercise on blood pressure is dependent on continued training. All patients will be followed up after one year.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AIT: aerobic interval training | Active Comparator | High intensity interval training on treadmill at > 90% of maximal HR for four bouts of four minutes with warm up, active pauses and cool down, three times per week for 12 weeks. |
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| MIT, moderate intensity training | Active Comparator | Moderate intensity treadmill continuous exercise at 70% of maximum heart rate for 47 minutes (in order to ensure isocaloric training amount), three times per week for 12 weeks. |
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| Recommendation of regular exercise | Active Comparator | No training intervention, general advice as prescribed in guidelines. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aerobic interval training | Behavioral |
| ||
| moderate intensity training |
| Measure | Description | Time Frame |
|---|---|---|
| 24 hour blood pressure | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Maximum oxygen uptake | 12 weeks | |
| Endothelial function | 12 weeks | |
| Echocardiographic left ventricular function |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Asbjorn Stoylen, Dr. Med | Dept. of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Norwegian University of Science and Technology | Trondheim | N-7489 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21450580 | Result | Molmen-Hansen HE, Stolen T, Tjonna AE, Aamot IL, Ekeberg IS, Tyldum GA, Wisloff U, Ingul CB, Stoylen A. Aerobic interval training reduces blood pressure and improves myocardial function in hypertensive patients. Eur J Prev Cardiol. 2012 Apr;19(2):151-60. doi: 10.1177/1741826711400512. Epub 2011 Mar 4. |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| Behavioral |
|
| Recommendation of regular exercise | Behavioral |
|
| 12 weeks |
| Quality of life | 12 weeks |