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| Name | Class |
|---|---|
| University Institute of Maia | OTHER |
| Cardiology Department, Hospital Infante D. Pedro, Centro Hospitalar do Baixo Vouga | UNKNOWN |
| Hypertension and Cardiovascular Unit, Hospital Pedro Hispano, ULS Matosinhos |
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The main purpose of this study is to assess whether exercise training reduces ambulatory blood pressure in patients with resistant hypertension. To accomplish these goals 60 patients with resistant hypertension will be recruited and randomized into exercise training or control groups and followed up for 6 months. The patients in the exercise group will participate in a 3-month outpatient program. The control group will receive usual medical care. At baseline, after the intervention and 3 months after the end of the intervention both groups will undergo several evaluations, including casual and ambulatory blood pressure, body composition, cardiorespiratory fitness, quality of life, arterial stiffness, autonomic function, and endothelial and inflammatory biomarkers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise group | Experimental | The 12-week exercise-training program will include three sessions of aerobic exercise per week |
|
| Control group | No Intervention | The control group will receive usual medical care |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise Group | Other | The 12-week exercise-training program will include three sessions of aerobic exercise per week |
|
| Measure | Description | Time Frame |
|---|---|---|
| Ambulatory blood pressure | Blood pressure | Change from Baseline in Blood Pressure at 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Casual blood pressure | Blood pressure | Change from baseline to 3 months |
| Body composition | Body composition | Change from baseline to 3 months |
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Inclusion Criteria: confirmed resistant hypertension, who in the previous 3 months had unchanged medication
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| José Mesquita Bastos, MD, PhD | Hospital Infante D. Pedro, Centro Hospitalar Do Baixo Vouga | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiology Department, Hospital Infante D. Pedro, Centro Hospitalar do Baixo Vouga | Aveiro | 3800 | Portugal | |||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37424233 | Derived | Lopes S, Diniz F, Mesquita Bastos J, Oliveira J, Polonia J, Alves AJ, Ribeiro F, Figueiredo D. "What do we think?": a qualitative exploratory study of acceptability and experiences of individuals with resistant hypertension after completing a physical exercise program (the EnRICH trial). Disabil Rehabil. 2024 Jun;46(12):2662-2669. doi: 10.1080/09638288.2023.2229237. Epub 2023 Jul 9. | |
| 34347008 |
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| Universidade do Porto | OTHER |
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| Health-related quality of life | Health-related quality of life will be evaluated by the Short-Form 36. | Change from baseline to 3 months |
| Arterial stiffness | Carotid-femoral pulse wave velocity, central pressures and aortic augmentation index and augmentation pressure. | Change from baseline to 3 months |
| Heart rate variability | Recordings of R-R interval data; The R-R interval will be analyzed using time domain, frequency domain and Poincare´ plot techniques. | Change from baseline to 3 months |
| Circulating number of endothelial progenitor cells, circulating endothelial cells, nitric oxide and endothelial Nitric Oxide Synthase | These markers will inform endothelial function, damage and repair | Change from baseline to 3 months |
| Inflammation | Plasma levels of inflammatory and anti-inflammatory biomarkers. | Change from baseline to 3 months |
| Oxidative stress | Plasma levels of oxidative stress and antioxidant markers. | Change from baseline to 3 months |
| Daily physical activity | Physical activity will be measured during 7 consecutive days using an accelerometer. | Change from baseline to 3 months |
| Dietary intake | Dietary intake will be assessed using a 4-day food diary. | Change from baseline to 3 months |
| VO2 max | VO2 max will be determined by the Chester step test. | Change from baseline to 3 months |
| Hypertension and Cardiovascular Unit, Hospital Pedro Hispano, ULS Matosinhos |
| Matosinhos Municipality |
| 4464-513 |
| Portugal |
| Derived |
| Lopes S, Mesquita-Bastos J, Garcia C, Bertoquini S, Ribau V, Teixeira M, Ribeiro IP, Melo JB, Oliveira J, Figueiredo D, Guimaraes GV, Pescatello LS, Polonia J, Alves AJ, Ribeiro F. Effect of Exercise Training on Ambulatory Blood Pressure Among Patients With Resistant Hypertension: A Randomized Clinical Trial. JAMA Cardiol. 2021 Nov 1;6(11):1317-1323. doi: 10.1001/jamacardio.2021.2735. |