Efficacy and Safety of Pactimibe in Patients With Atherosclerosis

Effect of Pactimibe on the Progression of Atherosclerosis as Measured by 2-D and 3-D Carotid Ultrasound

The effect of pactimibe on the reduction of atherosclerosis in the carotid artery will be assessed using carotid ultrasound

Inclusion Criteria:

• Increased cardiovascular risk (i.e. history of myocardial infarction, stroke, diabetes mellitus, left ventricular hypertrophy)
• Intima-media thickness greater than or equal to 0.8 mm as measured by ultrasonography
• Negative pregnancy test for females

Exclusion Criteria:

• Whole blood donation (greater than or equal to 450 ml) during the last three months before study start
• Unstable angina, congestive heart failure or uncontrolled hypertension
• Renal disease including nephrectomy and/or renal transplant
• Hepatic disease or abnormal liver function parameters
• Drug abuse or alcohol addiction