Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid

Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid: A Comparison of Clinical Efficacy

Melasma is an acquired discoloration of the skin characterized by brown patches. Chemical peels using agents such as Jessner's solution and trichloroacetic acid (TCA) are commonly used to treat melasma. A chemical peel involves applying the peeling agent to the skin for a short period. The skin will peel similar to a sunburn, and moisturizers are applied to the skin. Although both agents are well-accepted, there have been no good comparisons of the two agents. The purpose of this study is determine if there is a difference in the effectiveness of these two agents.

Inclusion Criteria:

• Adults > 18 years old
• Clinical diagnosis of melasma
• Mental capacity to give informed consent

Exclusion Criteria:

• Pregnancy
• H/o allergy to Jessner's solution, tricholoracetetic acid, tretinoin, or hydroquinone
• Active dermatitis
• Presence of cutaneous infection