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| ID | Type | Description | Link |
|---|---|---|---|
| AOR03003 |
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The researchers tested the hypothesis that a protein pulse-feeding pattern was more efficient in improving muscle mass and immune functions than was a protein spread-feeding pattern, after 45 days, in elderly malnourished patients.
To estimate the amelioration of the accretion in protein and the immunizing deficit thanks to a nutrition "PULSEE" ( to hold on 80 % of the proteic by day in on meal) with a proteic distributed all along the day for old subjects having a denutrition
To also estimate that the diminution of the morbidity decrease (infections, bedsores) the average during the stay and the mortality according to 2 modalities of grip nutritional
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Protein pulse-feeding |
|
| 2 | Active Comparator | Spread diet |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Protein pulse-feeding | Dietary Supplement | Dietary protein (80% of daily intake) was consumed in one meal (12.00h) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Lean mass (dual energy X-ray absorptiometry [DEXA] and bioelectrical-impedance analysis [BIA]) | 42 days |
| Measure | Description | Time Frame |
|---|---|---|
| Immune functions | 42 days | |
| Hand-grip strength | 42 days | |
| Biological nutritional parameters |
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Aussel Christian, PHD, PharmD | Assistance Publique Hopitaux de Paris:Laboratoire de Biologie de la Nutrition EA 2498 and Hôpital Emile Roux (AP-HP) | Study Director |
| Cynober Luc, PHD, PharmD | Assistance Publique Hopitaux de Paris:Laboratoire de Biologie de la Nutrition EA 2498 and Hôpital Hôtel-Dieu (AP-HP) | Study Chair |
| Bouillanne Olivier, MD | Assistance Publique Hopitaux de Paris:Laboratoire de Biologie de la Nutrition EA 2498 and Hôpital Emile-Roux (AP-HP) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Emile-Roux (AP-HP) | Limeil-Brévannes | 94456 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24355438 | Derived | Bouillanne O, Neveux N, Nicolis I, Curis E, Cynober L, Aussel C. Long-lasting improved amino acid bioavailability associated with protein pulse feeding in hospitalized elderly patients: a randomized controlled trial. Nutrition. 2014 May;30(5):544-50. doi: 10.1016/j.nut.2013.10.006. Epub 2013 Oct 14. | |
| 22992307 | Derived |
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| ID | Term |
|---|---|
| D011502 | Protein-Energy Malnutrition |
| ID | Term |
|---|---|
| D011488 | Protein Deficiency |
| D003677 | Deficiency Diseases |
| D044342 | Malnutrition |
| D009748 | Nutrition Disorders |
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| Spread diet | Dietary Supplement | Dietary protein was spread over the four meals. |
|
| 42 days |
| Mortality and morbidity (infections and bedsores) | 42 days |
| Activity of Daily Living (ADL) | 42 days |
| Plasmatic amino acid levels | 42 days |
| Bouillanne O, Curis E, Hamon-Vilcot B, Nicolis I, Chretien P, Schauer N, Vincent JP, Cynober L, Aussel C. Impact of protein pulse feeding on lean mass in malnourished and at-risk hospitalized elderly patients: a randomized controlled trial. Clin Nutr. 2013 Apr;32(2):186-92. doi: 10.1016/j.clnu.2012.08.015. Epub 2012 Aug 30. |
| D009750 |
| Nutritional and Metabolic Diseases |