Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy

Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy

Prevalence of chronic pain after mastectomy is beyond 50% 3 months after surgery. This pain is related to a sensitization of the central nervous system through N-methyl-D-asparate (NMDA) receptors. Ketalar might prevent the occurrence of chronic pain by anti-NMDA properties after mastectomy.

Inclusion Criteria:

• Mastectomy in patients 18 to 80 years old

Exclusion Criteria:

• American Society of Anesthesiology (ASA) class >= 3
• Renal, heart or hepatic failure
• Allergy to ketalar
• Psychiatric disease
• Chronic antalgic treatment