Administration of Ketamine to Prevent the Post-operative Pain

Effect of Ketamine, at the Induction and Its Maintenance to Prevent the Post-operative Pain: Clinical Trial in Cancerology

The surgery of breast cancer is responsible for post-operative pain, needing in about 30% some morphine consumption; like that, the association of ketamine with general anaesthesia may decrease morphine's use and so its adverse effects. The purpose is to evaluate the analgesic effect of a receptor NMDA's antagonist ( ketamine)

Inclusion criteria:

• Patients 18 years older
• ASA class 1 or 2
• with surgery of breast cancer (mastectomy or tumorectomy)

Exclusion criteria:

.Kétamine hypersensitivity

• Major psychiatric disorders
• Major cardio-vascular disorders
• Major neurologic disorders
• Major ocular disorders
• Morphine in pre-operative period