Effect of a Topical Ketamine on Acute and Chronic Pain, Dose Finding

Effect of a Topical Ketamine on Acute and Chronic Post-mastectomy Pain, Dose Finding - Clinical Study

The aim of this study is to investigate the effect of addition of different doses of Ketamine locally in acute and chronic post-mastectomy pain after breast cancer surgery and on the probability of developing chronic post-mastectomy pain.

Inclusion Criteria:

- American society of heart association class I-II female patients

• aged 18-60 years
• scheduled for modified radical mastectomy with axillary dissection for breast carcinoma

Exclusion Criteria:

• known allergy to the study drugs
• significant cardiac-
• respiratory-
• renal or hepatic disease