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The aim of this study is to investigate the effect of addition of different doses of Ketamine locally in acute and chronic post-mastectomy pain after breast cancer surgery and on the probability of developing chronic post-mastectomy pain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group (A) | Active Comparator | patients will receive 1mg / kg of Ketamine diluted by 20 ml saline (0.9 % ) |
|
| Group (B) | Active Comparator | patients will receive 2 mg /kg of Ketamine diluted by 20 ml saline (0.9 %) a |
|
| Group (C) | Active Comparator | patients will receive 3 mg / kg of Ketamine diluted by 20 ml saline (0.9 %) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| group (A) | Drug | patients will receive 1mg / kg of Ketamine diluted by 20 ml saline (0.9 % ) and irrigated onto surgical field after hemostats and before skin closure. |
|
| Measure | Description | Time Frame |
|---|---|---|
| the total amount of morphine consumption | total amount of rescue analgesia | 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| pain intensity | pain intensity measured by Visual analogue scale | 48 hours |
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Inclusion Criteria:
- American society of heart association class I-II female patients
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| South Egypt Cancer Instuite | Asyut | 171516 | Egypt |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| ID | Term |
|---|---|
| D044382 | Population Groups |
| ID | Term |
|---|---|
| D003710 | Demography |
| D011154 | Population Characteristics |
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| group (B) | Drug | patients will receive 2 mg /kg of Ketamine diluted by 20 ml saline (0.9 %) and irrigated onto surgical field after hemostasis and before skin closure. |
|
| group (c) | Drug | patients will receive 3 mg /kg of Ketamine diluted by 20 ml saline (0.9 %) and irrigated onto surgical field after hemostasis and before skin closure. |
|
| D017437 |
| Skin and Connective Tissue Diseases |