Islet Function in Gestational Diabetes

Islet Function in Gestational Diabetes

The purpose of this research is to understand how the function of the human pancreas changes during and after pregnancy.

Inclusion Criteria:

• Pregnant individuals with a viable singleton pregnancy who have completed second trimester gestational diabetes screening and are eligible for classification as either gestational diabetes mellitus or no gestational diabetes mellitus.
• Participants must be willing and able to provide informed consent and complete planned pregnancy and postpartum study visits.

Exclusion Criteria:

• Active systemic illness (e.g. chronic kidney disease, hypertension)
• Pre-pregnancy diabetes mellitus
• Multiple gestation, major fetal anomaly, or non-viable pregnancy on ultrasound
• Fasting glucose ≥ 100 mg/dL or HbA1c ≥ 5.7% in early pregnancy
• One abnormal value on the 3-hour 100 g oral glucose tolerance test
• Glucose at least 190 mg/dL on glucose challenge testing without subsequent 3-hour oral glucose tolerance testing
• Use of medication affecting glucose metabolism before pregnancy or in early pregnancy
• Use of glucose-lowering medication (e.g. metformin, glyburide) other than insulin to treat gestational diabetes mellitus in the current pregnancy
• History of upper gastrointestinal surgery that alters gastric emptying (e.g. bariatric surgery)
• Hemoglobin < than 11 g/dL