A Study to Evaluate the Effect of Genetic Variation on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetics

Effect of Genetic Variation in the GLP-1 Receptor on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetic Humans

The GLP-1 receptor (GLP1R) gene is found on the beta cells of the pancreas. Its role is in the control of blood sugar level by enhancing insulin secretion from the pancreas after eating a meal. The purpose of this research study to find out how genetic variations in GLP1R alter insulin secretion, in the fasting state and when blood sugars levels are elevated.

Inclusion Criteria:

• 40 nondiabetic subjects will be recruited.
• 20 subjects with the AA genotype at rs3765467 and remainder will have the GG genotype.
• Individuals encompassing the age span of 25-65 years.

Exclusion Criteria:

• Individuals under 25 and over 65 years of age.