Effects of Kefir on Celiac Disease

Effects of Kefir Consumption on Celiac Disease Symptoms

This study will investigate whether regular consumption of kefir can reduce gastrointestinal symptoms and improve quality of life in adults with celiac disease who follow a strict gluten-free diet. The study will use a randomized cross-over design in which participants will consume kefir during one study period and continue their usual diet without kefir during another period.

Celiac disease is a chronic autoimmune disease triggered by gluten consumption. Although a strict gluten-free diet is the only established treatment, some individuals continue to experience gastrointestinal symptoms and reduced quality of life.

The CeliKef study will investigate whether regular consumption of kefir may help alleviate gastrointestinal symptoms and improve quality of life in adults with celiac disease following a strict gluten-free diet. The study will include approximately 30 participants and will use a randomized cross-over design. Each participant will undergo a kefir consumption period and a period without kefir, separated by a washout period. Gastrointestinal symptoms and celiac disease-related quality of life will be assessed during the study.

Inclusion Criteria:

• Adults aged 18 years or older with a confirmed diagnosis of celiac disease.
• Following a strict gluten-free diet.

Exclusion Criteria:

• Other chronic gastrointestinal diseases.
• Pregnancy.
• Known allergy or intolerance to milk or dairy products or other components of kefir.