Role of Kynurenine Pathway and Its Metabolites in Depressive Disorders, Major Depressive Disorder is Suspected to Have the Greatest Burden by 2030,Kynurenine Pathway is Major Route Through Which the Essential Amino Acid Tryptophan is Metabolised and Activated in Time of Stress and Immune Activation.

Role of Kynurenine Pathway and Its Metabolites in Depressive Disorders

This is a case control study including simple random cases of 90 persons, 45 of them have depressive disorders and the other 45 are healthy individuals,age group between 18-60 years old, cases will be recruited from outpatient psychiatric clinic in sohag university hospital, all cases will be exposed to psychological assessment and also laboratory assessment of kynurenine metabolites by using biokits

Inclusion Criteria:

• age group 18: 60 years old
• cases are drug free of at least 4 months

Exclusion Criteria:

• patients with comorbid other psychiatric disorders( SUD,anxiety)
• patients with IQ below 90
• patients with psychotic features
• patients with postpartum depression
• patients with chronic medical illness that might affect immune function
• patients under treatment with immune modulating therapy