Not yet recruitingInterventionalNot ApplicableLast updated Aug 10, 2026

Impact of an Arginine-containing Toothpaste on the Subgingival Microbiota in Patients in Supportive Periodontal Care

Overview

ClinicalTrials.gov ID: NCT07755800
Lead Sponsor: Sukirth M Ganesan, BDS, PhDOTHER
Brief Summary: This study aims to see how a toothpaste with arginine affects bacteria below the gum line compared to a regular fluoride toothpaste. It focuses on people with gum disease who are already getting ongoing dental care.

The main questions it aims to answer are:

How does an arginine toothpaste affect the bacteria below the gumline?

How does a fluoride toothpaste affect the bacteria below the gumline?

Participants will:

Use fluoride toothpaste or arginine toothpaste twice daily for 6 months

After receiving the toothpaste at the baseline visit, subjects will visit the clinic at 3 months and 6 months for additional data collection.

Status

Overall Status: Not yet recruiting
Start Date: Aug 2026Estimated
Primary Completion Date: Jul 2028Estimated
Completion Date: Jul 2028Estimated

Study Record Dates

First Submitted: Aug 4, 2026
First Submitted that Met QC Criteria: Aug 4, 2026
First Posted: Aug 10, 2026Actual
Last Update Submitted that Met QC Criteria: Aug 4, 2026
Last Update Posted: Aug 10, 2026Actual
Last Verified: Apr 2026

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