Proof of concept clinical study to measure plaque metabolism and the prebiotic efficacy of arginine-containing toothpaste.

Inclusion Criteria:

• Signed Informed Consent Form.
• Male and female subjects aged 18-70 years, inclusive.
• Availability for the nine-week duration of the clinical research study.
• Good general health based on the opinion of the study investigator
• Good general health

Exclusion Criteria:

• Moderate and/or advanced periodontal disease, rampant caries, or any condition that the dental examiner considers exclusionary from the study.
• Five or more carious lesions requiring immediate care.
• Concurrent participation in any other oral care clinical study or test panel.
• Self-reported pregnant or lactating women.
• Dental prophylaxis received in the past four weeks prior to baseline examinations
• History of tobacco use-smoking, vaping and chewing tobacco
• Presence of orthodontic bands, presence of partial removable dentures
• Tumor(s) of the soft or hard tissues of the oral cavity
• Use of antibiotics or stain inducing medications any time during the two month prior to entry into the study
• Use of oral care products containing antimicrobials (Zn, Sn, CPC, triclosan, alcohol containing mouthwash, etc