Not yet recruitingObservationalLast updated Aug 7, 2026

A Prospective, Observational Study to Evaluate the Safety and Feasibility of Continuous Renal Replacement Therapy With Regional Citrate Anticoagulation in a Cohort Critical Ill Patients With Acute Kidney Injury and Presumed Absent Citrate Metabolism

Overview

ClinicalTrials.gov ID: NCT07751874
Lead Sponsor: University Hospital, AntwerpOTHER
Brief Summary: Use of regional citrate anticoagulation in an at risk population with decreased citrate metabolism. This study assesses the feasibility and safety of regional citrate anticoagulation in this population.
Study Type: Observational

Status

Overall Status: Not yet recruiting
Start Date: Oct 15, 2026Estimated
Primary Completion Date: Jan 1, 2028Estimated
Completion Date: Jul 1, 2028Estimated

Study Record Dates

First Submitted: Aug 3, 2026
First Submitted that Met QC Criteria: Aug 3, 2026
First Posted: Aug 7, 2026Actual
Last Update Submitted that Met QC Criteria: Aug 3, 2026
Last Update Posted: Aug 7, 2026Actual
Last Verified: Aug 2026

NCT07751861Completed

Metabolic Complications Using a Low- Versus High Concentration Citrate Solution for Regional Anticoagulation in Continuous Kidney Replacement Therapy: A Pragmatic Randomized Trial

NCT01269112Completed

Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy

NCT02486614Completed

Effect of Citrate on the Coagulation System in Patients Receiving CRRT

NCT02669589Completed

Investigating Different Anticoagulants for Renal Replacement Therapy

NCT02423642Completed

Immunomodulation Effect of Regional Citrate Anticoagulation in Acute Kidney Injury Requiring Continuous Renal Replacement Therapy

NCT07514650Recruiting

Validation of a Regional Citrate Anticoagulation Protocol in Critically Ill Patients on Continuous Renal Replacement Therapy