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The purpose of this study is to study the effect of anticoagulation in immune response with Acute Kidney Injury (AKI) undergoing Continuous Renal Replacement Therapy (CRRT).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AKI requring CRRT and use regional citrate anticoagulation | Experimental | CRRT use regional citrate anticoagulation |
|
| AKI requring CRRT and not use regional citrate anticoagulation | Experimental | CRRT not use regional citrate anticoagulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Continuous renal replacement therapy with regional citrate anticoagulation | Procedure | CRRT with anticoagulant : regional citrate anticoagulation Filter : AQUAMAX™ (Edwards Lifesciences) |
| Measure | Description | Time Frame |
|---|---|---|
| Functions of inflammatory cells | CD11b expression on PMN and HLA-DR expression on monocyte | 24 hours |
| Regulation of inflammatory reactions and and opsonization in microorganisms | C3a and C5a | 24 hours |
| Activity of acute phase protein during acute inflammation | PAI-1 | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| survival rate | 28 days | |
| length of ICU stay | 28 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sasipha Tachaboon | Bangkok | Pathumwan | 10330 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33314078 | Derived | Tsujimoto H, Tsujimoto Y, Nakata Y, Fujii T, Takahashi S, Akazawa M, Kataoka Y. Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy. Cochrane Database Syst Rev. 2020 Dec 14;12(12):CD012467. doi: 10.1002/14651858.CD012467.pub3. |
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|
| Continuous renal replacement therapy with no anticoagulation or heparin | Procedure | CRRT with any anticoagulant : no anticoagulation or heparin Filter : AQUAMAX™ (Edwards Lifesciences) |
|
|
| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
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| ID | Term |
|---|---|
| D000079664 | Continuous Renal Replacement Therapy |
| D006493 | Heparin |
| ID | Term |
|---|---|
| D017582 | Renal Replacement Therapy |
| D013812 | Therapeutics |
| D005112 | Extracorporeal Circulation |
| D013514 | Surgical Procedures, Operative |
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
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