Decoding the Neural Mechanisms Underlying Postural Instability and Gait Dysfunction in Parkinson's Disease | NCT07748962

NCT07748962

Overview

NCT ID: NCT07748962
Lead Sponsor: The Cleveland ClinicOTHER
Official Title: Decoding the Neural Mechanisms Underlying Postural Instability and Gait Dysfunction in Parkinson's Disease
Brief Summary: The purpose of this study is to learn how brain signals are related to freezing of gait (FOG) and balance problems in Parkinson's disease (PD) and to study how different deep brain stimulation (DBS) settings may affect these symptoms.
Conditions: Parkinson Disease
Freezing of Gait
Interventions: Multiple Deep Brain Stimulation (DBS) Conditions
Moving Overground in a Virtual Environment (MOVE)

Status and Timeline

Status: Not yet recruiting
Last Update Posted: Aug 6, 2026Actual
Start Date: Sep 18, 2026Estimated
Primary Completion Date: Mar 18, 2027Estimated

Participation Criteria

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

You have been diagnosed with Parkinson's disease

You already have a deep brain stimulation (DBS) device implanted as part of your medical care - specifically, the Medtronic Percept DBS device

Your DBS settings have been stable for at least 3 months

You experience freezing of gait (sudden inability to move your feet when trying to walk)

You are able to walk on your own for at least 10 minutes without assistance

You are willing to temporarily stop your Parkinson's medications and have your DBS settings adjusted for study testing

You are able to understand the study and provide consent to participate

Exclusion Criteria:

You have a neurological condition other than Parkinson's disease (such as stroke or multiple sclerosis)

You have been diagnosed with dementia or have difficulty understanding the study or giving consent

You currently have alcohol or substance abuse problems

You have hearing or vision problems that would make it difficult to use a virtual reality headset

You have any medical or mental health condition that, in the opinion of the study doctor, would make it unsafe or difficult for you to participate

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 5Estimated
Primary Purpose: Basic Science
Allocation: N/A
Interventional Model: Single Group Assignment
Masking

Contacts and Locations

Central Contacts: MacKenzie DunlapContact
dunlapm4@ccf.org

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