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Currently, there is a lack of comprehensive knowledge about the role of vestibulospinal drive and cortical activity during self-initiated movement transitions in older adults and people with PD (both with and without FOG). This set of experiments has two primary purposes: to (1) understand the pathological neurophysiology underlying freezing of gait (FOG) during movement transitions and FOG-inducing movements and (2) identify neurological biomarkers associated with FOG and FOG-inducing movements. To achieve this, the investigators will assess vestibular activity using the noninvasive neuromodulation technique of electrical vestibular stimulation (EVS, Experiments 1 and 2) and assess cortical activity by recording via electroencephalography (EEG, Experiments 3 and 4, no stimulation included). These experiments will investigate the vestibular (EVS Experiments) and cortical (EEG experiments) contributions to movement transitions during standing, walking, turning, and changing movement rates. Upon completion of this project, the investigators expect to provide a new understanding of key neural systems (vestibular and cortical) involved in the pathogenesis of movement impairment and freezing episodes during movement transitions including gait initiation, turning, and changing movement rates, in people with PD. An increased understanding of the temporal dynamics of systems involved in FOG and FOG-inducing movements could later guide the development and delivery of novel interventions (e.g. closed-loop deep brain stimulation [DBS] or non-invasive brain stimulation) to decrease the incidence and severity of FOG episodes, reducing fall risk and morbidity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PD with FOG | Experimental | People with Parkinson's disease and freezing of gait: n = 25 in experiments 1 and 2, 20 in experiments 3 and 4. (Up to 90 participants, if each participant only volunteers for one study, however, the investigators anticipate a significant overlap and that most participants will volunteer for multiple experiments). |
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| PD without FOG | Experimental | n = 25 in experiments 1 and 2, 20 in experiments 3 and 4. (Up to 90 participants, as in Group 1.) |
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| Old adults matched controls | Active Comparator | (age- and sex-matched to the group with Parkinson's disease and freezing of gait): n = 25 in experiments 1 and 2, 20 in experiments 3 and 4. (Up to 90 participants, as in Group 1.) |
|
| young adults matched controls | Active Comparator | Young adults (age 21-44) n = 25 in experiments 1 and 2, 20 in experiments 3 and 4. (Up to 90 participants, as in Group 1.) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EVS and EEG | Device | The participant can choose to participate in one or more of the following experiments. (Any two of these visits will be separated by at least one week.) Experiment 1: EVS during gait initiation (forward stepping, 2 visits) Experiment 2: EVS during turning (1 visit) Experiment 3: EEG during gait initiation (forward stepping, 1 visit) Experiment 4: EEG during RAMS (1 visit) vestibular activity will be assessed using the noninvasive neuromodulation technique of electrical vestibular stimulation (EVS, Experiments 1 and 2) and cortical activity will be assessed by recording via electroencephalography (EEG, Experiments 3 and 4, no stimulation included). |
| Measure | Description | Time Frame |
|---|---|---|
| timing of trunk muscle torque production | Onset and offset times of the trunk muscle activity, relative to the start of the turn, as measured by electromyography sensors | one day |
| amplitude of trunk muscle torque production | Magnitudes of trunk muscle activity during the turn, as measured by electromyography sensors | one day |
| ground reaction force | The forces resulting from the participant pushing into the floor during turns and gait initiation, as measured by force plates under the feet | up to 3 days |
| center of pressure measures of turning and stepping | Participants will complete right/left 90 degree turns from standing on a pair of force plates (Kistler) | up to 3 days |
| body segmental angular velocity | The speed at which different body parts (e.g., head, thoracic spine, etc.) rotate during a turn, as measured by 24 reflective markers at various bony landmarks on the head, trunk, pelvis, and lower extremities, used to capture the whole-body kinematic motion via optical motion capture various bony landmarks on their head, trunk, pelvis, and lower extremities to capture whole-body kinematic motion via optical motion capture (Simi Motion). | one day |
| motion onset | Time of initial movement of the body, as measured by 24 reflective markers at various bony landmarks on the head, trunk, pelvis, and lower extremities, used to capture the whole-body kinematic motion via optical motion capture various bony landmarks on their head, trunk, pelvis, and lower extremities to capture whole-body kinematic motion via optical motion capture (Simi Motion). |
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Inclusion Criteria:
Participants with Parkinson's disease (with and without Freezing of Gait)
Exclusion Criteria:
Exclusion Criteria (for all participants):
Additional exclusion criteria for EVS Experiments (Experiments 1 and 2):
Additional exclusion criteria for Control Participants:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Madison Aasen, MS | Contact | 612-505-8325 | aasen056@umn.edu | |
| Sommer Amundsen-Huffmaster, PhD | Contact |
| Name | Affiliation | Role |
|---|---|---|
| Sommer Huffmaster, PhD | University of Minnesota | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Minnesota, Movement Disorders Lab | Recruiting | Minneapolis | Minnesota | 55455 | United States |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D004569 | Electroencephalography |
| ID | Term |
|---|---|
| D003943 | Diagnostic Techniques, Neurological |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D004568 | Electrodiagnosis |
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The study will use a cross-sectional design to examine the effects of group (PD with FOG vs. PD without FOG vs. matched controls; older adults vs. younger adults)
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|
| up to 3 days |
| total distance excursion | Distance moved, as measured by 24 reflective markers at various bony landmarks on the head, trunk, pelvis, and lower extremities, used to capture the whole-body kinematic motion via optical motion capture various bony landmarks on their head, trunk, pelvis, and lower extremities to capture whole-body kinematic motion via optical motion capture (Simi Motion). | up to 3 days |
| Movement amplitude | Size of the movements, as measured by the manipulandum during repetitive movements | one day |
| speed during the slow and fast epochs | Speed of the movements, as measured by the manipulandum during repetitive movements | one day |
| duration of freezing events | Length of time during which movements are drastically decreased in size or speed nears zero, as measured by the manipulandum during repetitive movements | one day |
| EVS coherence |
coherence between trunk/leg muscle activation and EVS, coherence between ground reaction forces and EVS. | up to 2 days |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |