Respiratory, Limb Muscle Properties, and Physical Performance in Adult Lung Transplant Recipients | NCT07747337

NCT07747337

Overview

NCT ID: NCT07747337
Lead Sponsor: University of FloridaOTHER
Official Title: Respiratory, Limb Muscle Properties, and Physical Performance in Adult Lung Transplant Recipients
Brief Summary: The goal of this observational study is to evaluate respiratory and limb muscle properties in adults awaiting lung transplantation and determine how these measures relate to physical performance, symptoms, and recovery after transplantation. Respiratory and limb muscle weakness may contribute to impaired mobility, frailty, and delayed postoperative recovery, but their specific role in lung transplant candidates is not well understood. Participants will undergo muscle ultrasound imaging at weekly basis, respiratory and limb strength testing, physical performance assessments, and symptom questionnaires once before and after transplantation. Researchers will also collect information from medical records regarding intensive care unit stay, hospital length of stay, rehabilitation participation, and postoperative recovery outcomes.
Conditions

Status and Timeline

Status: Recruiting
Last Update Posted: Aug 5, 2026Actual
Start Date: Feb 5, 2026Actual
Primary Completion Date: Dec 2026Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

18 years or older.

Hospitalized as potential candidates for single- or bilateral-lung transplant surgery.

Hemodynamically stable for out-of-bed mobilization

Exclusion Criteria:

Baseline cognitive impairment

History of previous solid organ transplantation or thoracic surgery

Existing phrenic nerve lesion

Lower limb amputation or fracture

External fixators or open wounds of the lower extremities

Diagnosed neuromuscular disorder.

Morbid obesity (body mass index >45 kg/m²).

Any other medical condition that, in the opinion of the investigators, would make participation unsuitable.

Study Plan

Study Type: Observational
Phase: No data available
Enrollment: 36Estimated
Primary Purpose: No data available
Allocation: No data available
Interventional Model: No data available
Masking

Contacts and Locations

Central Contacts: Barbara K Smith, PhD, PTContact
bksmith@ufl.edu

Similar Studies

Participant Group/Arms

Adult Lung Transplant Candidates

adults enrolled for in-hospital evaluation for lung transplant and listed for surgery who undergo serial assessments of respiratory and limb muscle properties before transplantation and during the early postoperative period. Assessments include ultrasound imaging, respiratory and limb strength testing, physical performance measures, patient-reported outcomes, and collection of clinical outcomes from the medical record.

Diagnostic Test: Respiratory and Limb Muscle Assessment

Locations

UF Health Shands Medical CenterRecruiting

Gainesville, Florida 32608, United States

Mindaugas Rackauskas, MD, PhDContact

mindaugas.Rackauskas@surgery.ufl.edu(352) 265-5470

Mohammad A. Aladaileh, MBBS, MRCSI, EBCTS, FRCSIC-ThContact

maladaileh@ufl.edu(352) 265-5470

Barbara K Smith, PhDPrincipal Investigator

Wagner Souza Leite, PTSub-Investigator

Sandra Morgan, RN, PhDSub-Investigator

Jessica Cornman, PTSub-Investigator

May Smith-Hublou, PhD, CCC-SLPSub-Investigator

Ushna Khan, MDSub-Investigator

Amir M Emtiazjoo, MD, MScSub-Investigator

Marc O Maybauer, MD, PhD, EDIC, FCCP, FACC, FASSub-Investigator

NCT03548857Unknown status

Muscle Function After Lung Transplantation in Patients With Chronic Obstructive Pulmonary Disease (COPD)

NCT06268171Completed

Ultrasound Assessment of Rectus Femoris Cross-sectionnal Area Following Lung Transplantation

NCT03668483Completed

Relation Between Muscle Strength With Exercise Capacity and Dyspnea in LTx

NCT06655181Completed

Evaluating the Effectiveness of Respiratory Muscle Training in Pediatric Kidney Transplant Patient

NCT03130608Completed

Inspiratory Muscle Training Post-Liver Transplant

NCT07065981Completed

Upper Limb Exercise Capacity: Lung Transplant vs. Healthy Controls

NCT06190171Recruiting

Respiratory Strength Training in Heart Transplant Recipients

NCT01080703Completed

To Determine if a Lower Extremity Strengthening Program Improve Quadriceps Muscle Strength