The aim of the present study is to assess whether cumulative endogenous neurophysin I secretion over one month differs between premenopausal and postmenopausal women. Using repeated measurements of neurophysin-I (NP-I, equimolar surrogate marker of oxytocin) across defined physiological time points, this study investigates oxytocin system regulation under cyclic and non-cyclic hormonal conditions.
The primary hypothesis is that cumulative NP-I release, expressed as the area under the curve (AUC) is lower in the postmenopausal group compared to the premenopausal group.
Inclusion Criteria:
Premenopausal group:
• Premenopausal women aged 18-35 years with regular menstrual cycles (21-35 days) for ≥3 months prior to study entry
Postmenopausal group:
• Postmenopausal women ≥2 years of postmenopause (i.e. 3 years since last menstrual period (LMP), with menopause defined as ≥ 12 months of amenorrhea)
Exclusion Criteria:
Mirjam.Christ-Crain@usb.ch
Postmenopausal women, visits will take place during the menstrual phase, mid-follicular phase, ovulation, and mid-luteal phase, with a scheduling tolerance of ± 2days.
Premenopausal women, visits will take place during the menstrual phase, mid-follicular phase, ovulation, and mid-luteal phase, with a scheduling tolerance of ± 2days.
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