Effect of Chronic Intranasal Oxytocin Administration on Sexual Function in Pre- and Postmenopausal Women

Female Sexual Dysfunction in the Menopause: Effect of Intranasal Oxytocin Administration on Sexual Function and Activity

The purpose of this study is to determine whether intranasal oxytocin is effective in comparison to placebo in improving female sexual dysfunction in pre- and postmenopausal women.

Inclusion Criteria:

• Willingness to attempt sexual intercourse and/ or masturbation at least two times per week
• Ongoing relationship for at least 3 months
• Female subjects aging 40 years and more, Male subjects must be older than 18
• The participation in this study should be of free choice to male partners
• Willingness to perform a pregnancy test every month (for pre-menopausal subjects)
• Willingness to use contraception during the study period (for pre-menopausal subjects)
• Normal findings in the urogenital tract unless the investigator considers an abnormality to be clinically irrelevant
• Normal laboratory values unless the investigator considers an abnormality to be clinically irrelevant
• Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant

Exclusion Criteria:

• Primary sexual dysfunction
• sexual abuse
• severe psychiatric diseases
• untreated conditions and medication intake with associated reduction of sexual function.
• In male partners: any severe andrological or related medical problem.