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The aim is to examine whether intranasal oxytocin will influence the individuals' emotion regulation ability and related neural mechanisms.
In the present study, the investigators plan to conduct a between-subject, double-blind, placebo-controlled experiment to investigate the effects of oxytocin on neural, physiological and behavior activity related to emotion regulation. The emotion regulation ability will be assessed by emotional go-nogo task and cognitive reappraisal task. The neural activity will be explored by functional magnetic resonance imaging (fMRI). And the investigators will record participants' heart rate during fMRI to investigate the effects of oxytocin on heart rate variability in emotion regulation process.
All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety before self-administration, including Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), Cheek and Buss shyness Scale (CBSS), Autism Spectrum Quotient (ASQ), Empathy Quotient (EQ), Interpersonal Reactivity Index (IRI), Action Control Scale (ACS), Emotion Regulation Questionnaire (ERQ), Berkley Expressivity Questionnaire (BEQ), and so on.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oxytocin | Experimental | intranasal administration of oxytocin |
|
| Placebo | Placebo Comparator | intranasal administration of placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oxytocin | Drug | intranasal administration of oxytocin |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Oxytocin effects on neural activity during emotion regulation task | Neural activity will be measured by functional magnetic resonance imaging (fMRI). Differences in activity of prefrontal cortex (PFC) and amygdala will be compared between oxytocin and placebo groups during emotional go-nogo task and cognitive reappraisal task. | Between 45-110 minutes after the intranasal administration of oxytocin |
| Measure | Description | Time Frame |
|---|---|---|
| Oxytocin effects on heart rate variability during emotion regulation task | The heart rate will be recorded during the fMRI. The effects of oxytocin will be assessed by determining changes in heart rate variability between oxytocin and placebo groups during emotional go-nogo task and cognitive reappraisal task. | Between 45-110 minutes after the intranasal administration of oxytocin |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Weihua Zhao, Master | Contact | zarazhao.uestc@outlook.com |
| Name | Affiliation | Role |
|---|---|---|
| Keith Kendrick, Dr. | University of Electronic Science and Technology of China | Study Director |
| Benjamin Becker | University of Electronic Science and Technology of China | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| School of Life Science and Technology, University of Electronic Science and Technology | Recruiting | Chengdu | Sichuan | 611731 | China |
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| ID | Term |
|---|---|
| D000080103 | Emotional Regulation |
| ID | Term |
|---|---|
| D000068356 | Self-Control |
| D012919 | Social Behavior |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D010121 | Oxytocin |
| ID | Term |
|---|---|
| D010909 | Pituitary Hormones, Posterior |
| D010907 | Pituitary Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
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| Placebo | Drug | intranasal administration of placebo |
|
|
| Oxytocin effects on behavior response during emotion regulation task | The effects of oxytocin will be assessed by determining changes in reaction time and accuracy during emotional go-nogo task and negative affect ratings during cognitive reappraisal task between oxytocin and placebo groups. | Between 45-110 minutes after the intranasal administration of oxytocin |
| Oxytocin effects on heart rate variability during resting-state | The heart rate will be recorded during the resting-state. The effects of oxytocin will be assessed by determining changes in heart rate variability between oxytocin and placebo groups during resting-state. | Between 35-45 minutes after the intranasal administration of oxytocin |
| Oxytocin effects on neural activity during resting-state | The effects of oxytocin will be assessed by determining changes in neural activity between oxytocin and placebo groups during resting-state. | Between 35-45 minutes after the intranasal administration of oxytocin |
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |