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NCT07741773

Overview

NCT ID: NCT07741773
Lead Sponsor: Augusta UniversityOTHER
Official Title: Dietary Supplementation With EVOO Phenolics Prevents MCI Progression to Alzheimer's Disease
Brief Summary: The goal of this clinical trial is to determine whether the extra-virgin olive oil (EVOO) phenolic dietary supplement can improve memory function and modulate biomarkers among individuals with mild cognitive impairment (MCI). The main questions it aims to answer are:

Does dietary supplementation with EVOO phenolics improve cognitive function?

What would be the effect of the EVOO dietary supplement on other MCI-related biomarkers, including vascular function and biological pathways?

Researchers will compare the EVOO dietary supplements with a placebo (a look-alike substance that contains no EVOO phenolics)

Participants will:

Take EVOO dietary supplements or a placebo daily for 6 months

Visit the study site during the 6-month study for screening and testing.
Conditions

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

CDR (Clinical Dementia Rating) score of 0.5 OR MoCA (Montreal Cognitive Assessment) score of 18-25.

Exclusion Criteria:

History or presence of vascular disease that may affect cognitive function

History or presence of stroke within the past 1 year

Recent transient ischemic attack (TIA) within the past 180 days

History of severe, clinically significant CNS trauma

History of intracranial tumor

History or presence of kidney disease (eGFR <60 mL/min/1.73m2)

Presence of a pacemaker

Presence of metal in the body

Allergic to the MRI contrast agent "Multihance"

Pregnancy