Retinopathy of prematurity (ROP) is a disorder of development of the retina and its vasculature that can impact vision in vulnerable preterm neonates for a lifetime. A major barrier to improving ROP outcomes is the lack of easy access and low stress means to obtain objective measures of ROP disease severity across the retina in these infants. The long-term goal of this program is to provide information which will improve preterm infant health and vision via objective bedside imaging and analysis that characterizes retina-wide ROP level of disease, its response to treatment and development, and to rapidly translate this for better early intervention and improved future vision care.
Inclusion Criteria:
Exclusion Criteria:
xi2.chen@duke.edu919-684-8434
While all participants have the investigational imaging, throughout image grading, the principal investigator and image analysts are masked to all health data (including retinopathy of prematurity examination findings) except age at time of imaging.
175 infants at risk for retinopathy of prematurity will be enrolled and have beside ultra-widefield OCT retinal imaging and standard-of-care binocular indirect ophthalmoscopic (BIO) exam.
455 infants at risk for retinopathy of prematurity: 175 infants will be enrolled and have beside ultra-widefield OCT retinal imaging, fundus imaging, and binocular indirect ophthalmoscopic exam. Data from newly enrolled infants will be combined with 280 infants who had similar imaging in BabySTEPS1, BabySTEPS2, and the Duke Investigational Pediatric OCT study to perform artificial intelligence (AI) based RW-ROP and TR-ROP severity assessment and to add OCT risk measures to AI-based prediction of RW-ROP and TR-ROP.
45 infants treated for ROP: Compare OCT measures to clinical findings of ROP regression and identify early signs of ROP reactivation.
michelle.mccall@duke.edu919-684-0544
Durham, North Carolina 27705, United States
xi2.chen@duke.edu919-684-8434
michelle.mccall@duke.edu919-684-0544
Retinal Microanatomy in Retinopathy of Prematurity (BabySTEPS2)
Analyzing Retinal Microanatomy in ROP
Clinical and Genetic Analysis of ROP
Point-of-Care Ophthalmic Diagnostic Imaging of Retinopathy of Prematurity
Optos Versus Indirect Ophthalmoscopy for ROP Screening Examination (Optos vs BIO Study)
Imaging Retinal Vasculature in Infant Eyes
Telemedicine Approaches to Evaluating Acute-phase ROP
Feasibility of Nurse-led Retinal Imaging for Retinopathy of Prematurity Screening Employing the Optos California