Validation of an Effort-Based Cough Peak Flow Algorithm to Predict Extubation Outcomes | NCT07737483

NCT07737483

Overview

NCT ID: NCT07737483
Lead Sponsor: Hospital H+ QueretaroOTHER
Official Title: Validation of an Effort-Based Cough Peak Flow Algorithm to Predict Extubation Outcomes in the ICU: A Prospective Blinded Cohort Study
Brief Summary: This study aims to prospectively validate the diagnostic accuracy of an effort-stratified Cough Peak Flow (CPF) decision algorithm for predicting extubation failure, maintaining strict blinding of the clinical team. The model classifies patients by neurological status and uses an effort-based approach, including a "Gray Zone" (40-59 L/min) managed by tidal volume evaluation.
Conditions: Extubation Failure
Interventions

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No data available
Eligibility Criteria: Inclusion Criteria:

Adult patients (≥18 years) admitted to the ICU who received invasive mechanical ventilation for >24 hours and successfully completed a Spontaneous Breathing Trial (SBT).

Exclusion Criteria:

Prior indication for tracheostomy (e.g., severe maxillofacial trauma, upper airway obstruction).

Self-extubation or accidental extubation.

Decision to withhold or withdraw life-sustaining treatments.

Severe primary neuromuscular diseases.