The goal of this clinical trial is to learn if high-frequency rTMS works to treat etomidate addiction in adults. It will also learn about the safety and tolerability of rTMS. The main questions it aims to answer are:
Researchers will compare active rTMS to sham rTMS to see if active rTMS works to treat etomidate addiction.
Participants will:
Attend follow-up assessments up to 6 months after baseline
Inclusion Criteria:
Able to read and communicate in English and/or Chinese
Able to give informed consent and/or able to provide an informed consent from the legal guardian (if applicable)
Using etomidate and/or its related analogues as the primary psychoactive substance of abuse
Suffering from etomidate addiction as defined by:
Exclusion Criteria:
Age < 18 years old
Unable to read English or Chinese
Unable to give informed consent
Had been diagnosed with the following disorders including:
1. Neurodevelopmental Disorders:
DSM-5: Intellectual Disabilities, Communication Disorders, Specific Learning Disorder, Autism Spectrum Disorder and Motor Disorders
International Statistical Classification of Diseases and Related Health Problems 11th Revision (ICD-11): Disorders of intellectual development (6A00), Developmental speech or language disorders (6A01), Autism spectrum disorder (6A02), Developmental learning disorder (6A03), Developmental motor coordination disorder (6A04), Stereotyped movement disorder (6A06), Primary tics or tic disorders (8A05.0)
Other DSM-5 defined Substance Use Disorder greater than moderate in severity (i.e., severity score ≥4)
Neurocognitive Disorders (DSM-5, or ICD-11 6D70-72 & 6D80-86) 2. Contra-indicated to undergo rTMS:
with electronic and/or magnetic implants (e.g., pacemaker, implantable cardioverter defibrillator [ICD], cerebral shunts, cochlear implant, etc.)
with metallic or mechanic fragments (e.g., screws, plates, stents, clips, etc.)
pregnant
with any known or history of neurological conditions including cerebral vascular accidents (CVA), epilepsy, brain tumor or space occupying lesion, etc.
poorly controlled or unstable diabetes mellitus
receiving unstable dose(s) of antipsychotics, antidepressants, benzodiazepines and/or anticonvulsants in the past 3 months
Chungkka@hku.hk+85260440993
Subjects receive 20 high-frequency rTMS sessions over 4 weeks.
Subjects receive 20 Sham rTMS sessions over 4 weeks.
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