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NCT07736573

Overview

NCT ID: NCT07736573
Lead Sponsor: Beijing Chao Yang HospitalOTHER
Official Title: A Retrospective Cohort Study of Invasive Vagus Nerve Stimulation Paired With Rehabilitation for Upper Limb Dysfunction After Stroke
Brief Summary: This study evaluated the feasibility, safety, and preliminary functional outcomes of invasive vagus nerve stimulation (iVNS) paired with upper-limb rehabilitation in participants with chronic stroke-related upper-limb motor dysfunction. Participants received cervical iVNS implantation followed by a 6-week supervised rehabilitation program and subsequent home-based rehabilitation. Changes in upper-limb motor function, spasticity, quality of life, and safety outcomes were assessed. Exploratory neuroimaging assessments using positron emission tomography/computed tomography and arterial spin labeling were performed in selected participants to evaluate changes in brain metabolism and perfusion.
Conditions: Stroke
Upper Extremity Motor Function

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Adults aged 18 years or older.

Documented history of stroke with persistent upper-limb motor dysfunction.

Completion of invasive vagus nerve stimulation implantation.

Completion of paired upper-limb rehabilitation after stimulation.

Availability of clinical assessments during follow-up.

Exclusion Criteria:

Other central nervous system disorders affecting motor function assessment.

Severe disturbance of consciousness or inability to complete standardized functional assessments.

Severe cognitive, communication, musculoskeletal, or peripheral nerve disorders interfering with upper-limb function evaluation.

Missing key clinical or follow-up data.