Tissue Adhesive vs Silk Sutures After Mandibular Third Molar Extraction | NCT07735598

NCT07735598

Overview

NCT ID: NCT07735598
Lead Sponsor: University of Turin, ItalyOTHER
Official Title: Clinical and Immunological Evaluation of Tissue Adhesive vs. Silk Suture for Primary Closure of Surgical Flaps After Mandibular Third Molar Extractions: a Split-mouth Randomized Controlled Trial
Brief Summary: Summary: This study compares two methods used to close the gum after the surgical removal of impacted lower wisdom teeth: a medical tissue adhesive and traditional silk sutures. Both closure techniques are evaluated for postoperative pain, bleeding, healing, and the local inflammatory response.
Conditions: Mandibular Third Molar/Surgery
Interventions

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Adults aged 18 years or older.

Healthy individuals (ASA I or II) with no history of uncontrolled systemic disease.

Presence of bilateral partially or completely impacted mandibular third molars requiring surgical extraction.

Comparable clinical and radiographic characteristics of both mandibular third molars.

Ability and willingness to provide written informed consent.

Willingness and ability to comply with the study protocol and attend all scheduled follow-up visits.

Exclusion Criteria:

Age younger than 18 years.

Absence of bilateral impacted mandibular third molars requiring surgical extraction.

Pregnancy or breastfeeding.

Current smoking.

Uncontrolled systemic diseases or medical conditions affecting wound healing or bone metabolism.

Oncological or hematological disorders.

Inability or unwillingness to provide informed consent or comply with the study protocol and follow-up schedule.