Postoperative pain remains a major challenge after video-assisted thoracoscopic surgery (VATS), despite the use of multimodal analgesia. This randomized, triple-blind, placebo-controlled clinical trial will evaluate whether adding a 5 mcg/hour transdermal buprenorphine patch to the standard multimodal analgesic regimen reduces postoperative pain in adults undergoing unilateral VATS. Participants will be randomly assigned to receive either transdermal buprenorphine or placebo in addition to standard analgesia. Postoperative pain will be assessed at 24, 48, and 72 hours and 7 days after surgery. Secondary outcomes include opioid rescue requirements, length of hospital stay, postoperative nausea and vomiting, pruritus, and urinary retention.
Inclusion Criteria:
Exclusion Criteria:
Participants, care providers, investigators responsible for outcome assessment, and the study statistician will remain blinded to treatment allocation. Participants in both groups will receive an identical opaque dressing to maintain masking. Randomization codes will remain concealed until completion of the statistical analysis.
Participants will receive a 5 mcg/hour transdermal buprenorphine patch before surgery in addition to standard multimodal analgesia.
Participants will receive a placebo transdermal patch before surgery in addition to standard multimodal analgesia.
Santiago, Santiago Metropolitan 8431657, Chile
alejandra.rivera@davila.cl930363776
bmiranda@davila.cl+56930363776
Transdermal Buprenorphine Patch for Laparoscopic Cholecystectomy
Comparison of the Efficacy and Safety of Intravenous Buprenorphine Administered Via PCA System Versus Oxycodone in the Management of Postoperative Pain After Video-Assisted Thoracoscopic Surgery
Comparative Efficacy of Buprenorphine Transdermal Patch Versus Tramadol in Postoperative Analgesia for Shoulder Arthroscopy
Safety of the Buprenorphine Transdermal Delivery System in Subjects With Mod-to-Sev Pain Following Orthopedic Surgery.
Intrapleural Bupivacaine Analgesia for Postoperative Pain Management After Minimally Invasive Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Trial
Study of Buprenorphine Sublingual Spray for the Treatment of Moderate to Severe Pain
Liposomal Bupivacaine for Pain Control Following Thoracic Surgery.
Postoperative Analgesia With Buprenorphine for Postoperative Pain Control and Quality of Life After Spinal Surgery