Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry | NCT07732686

NCT07732686

Overview

NCT ID: NCT07732686
Lead Sponsor: University of OklahomaOTHER
Official Title: Breath Volatile Organic Compounds (VOC) Analysis Using Proton Transfer Reaction Mass Spectrometry (PTR-MS)
Brief Summary: The purpose of this clinical trial is to evaluate whether volatile organic compound (VOC) signatures detected in the breath of patients with cancer can serve as a potential screening tool for the early detection of cancer.
Conditions: Pancreas Cancer
Hepatocellular Carcinoma
Lung Cancer
Ovarian Cancer
Breast Cancer
Head and Neck Cancer
Colon Cancer
Bladder Cancer
Other Cancer

Status and Timeline

Status: Not yet recruiting
Last Update Posted: Jul 29, 2026Actual
Start Date: Oct 2026Estimated
Primary Completion Date: Oct 2027Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: Yes
Eligibility Criteria: Inclusion Criteria:

Age ≥ 18 at the time of consent. Male and female patients to be tested.

Capable of understanding written and/or spoken English language.

Able to provide informed consent.

Cancer of any type.

Newly diagnosed cancer and untreated or established diagnosis of cancer. For established cancer patients, no active anti-cancer treatment for more than one month (reasons for no treatment are such as relapse, progression of cancer, refractory, or intolerance to treatment etc.)

Exclusion Criteria:

Under the age of 18.

Anticipated inability to complete breath sampling procedure.

Unable to provide informed consent.

Pregnant women

Active respiratory infection symptoms

Recent use of antibiotics

Difficulty in performing coached exhalation

Individuals who are unable to follow the instructions

Cancer patients who are on active treatment for cancer or have received cancer treatment within one month

Study Plan

Study Type: Observational
Phase: No data available
Enrollment: 2,000Estimated
Primary Purpose: No data available
Allocation: No data available
Interventional Model: No data available
Masking: No data available

Contacts and Locations

Central Contacts: Lead Onco NurseContact
SCC-IIT-Office@ouhsc.edu405-271-8777

Similar Studies

Participant Group/Arms

Diagnosed Malignancies

Participants in this group either have a newly diagnosed, untreated cancer or a pre-existing cancer diagnosis but are not currently receiving anticancer therapy. Participants with a pre-existing diagnosis must not have received any anticancer treatment within the previous month.

Device: Proton Transfer Reaction Mass Spectrometry Analysis

Healthy Control Group

Participants in this control group have no current or prior diagnosis of a malignancy.

Device: Proton Transfer Reaction Mass Spectrometry Analysis