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NCT07729787

Overview

NCT ID: NCT07729787
Lead Sponsor: Riphah International UniversityOTHER
Official Title: Comparative Effects of Autogenic Drainage and Mechanical Percussion on Lung Function, Dyspnea and Quality of Life in Children With Cystic Fibrosis
Brief Summary: The goal of this clinical trial is to compare the effects of autogenic drainage and mechanical percussion on lung function, dyspnea, and quality of life in children with cystic fibrosis.

The main questions it aims to answer are:

Does autogenic drainage improve lung function more effectively than mechanical percussion in children with cystic fibrosis?

Does autogenic drainage reduce dyspnea (breathlessness) more effectively than mechanical percussion?

Does autogenic drainage improve health-related quality of life more effectively than mechanical percussion?

Researchers will compare autogenic drainage with mechanical percussion to determine which airway clearance technique provides greater benefits for children with cystic fibrosis.

Participants will:

Be randomly assigned to receive either autogenic drainage or mechanical percussion therapy.

Participate in supervised treatment sessions five times per week for six weeks.

Undergo assessments of lung function using spirometry (FEV₁ and FVC), dyspnea using the Modified Borg Dyspnea Scale, and quality of life using the Cystic Fibrosis Questionnaire-Revised (CFQ-R) before and after the intervention period.

The findings of this study may help identify the most effective airway clearance technique for improving respiratory health and quality of life in children with cystic fibrosis.

Status and Timeline

Status: Recruiting
Last Update Posted: Jul 28, 2026Actual
Start Date: Jun 14, 2026Actual
Primary Completion Date: Nov 30, 2026Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Child (0-17)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Confirmed diagnosis of cystic fibrosis (CF) through a sweat test or genetic testing.

Age between 6 and 12 years.

Clinically stable condition (no acute pulmonary exacerbation within the last 4 weeks).

Exclusion Criteria:

History of thoracic surgery.

Active hemoptysis.

Severe physical or cognitive disabilities limiting participation in the intervention or assessments.

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 32Estimated
Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Single

Contacts and Locations

Central Contacts: Imran Amjad, PhDContact
imran.amjad@riphah.edu.pk03324390125

Similar Studies

Participant Group/Arms

Autogenic Drainage GroupExperimental

Participants assigned to this arm will receive therapist-guided autogenic drainage, an airway clearance technique that uses controlled breathing at different lung volumes to mobilize secretions from peripheral to central airways. Treatment sessions will be administered five times per week for six weeks, with each session lasting approximately 10 minutes under physiotherapist supervision.

Procedure: Autogenic Drainage

Mechanical Percussion GroupExperimental

Participants assigned to this arm will receive mechanical chest percussion therapy using a high-frequency percussion device to facilitate airway secretion clearance. Treatment sessions will be administered five times per week for six weeks, with each session lasting approximately 10 minutes under physiotherapist supervision.

Device: Mechanical Percussion