Effects of AD on VI in Patients With CF

Effects of Autogenic Drainage on Ventilation Inhomogeneity in Patients With Cystic Fibrosis

This study will investigate the effects of a chest physiotherapy manual technique (autogenic drainage) on ventilation inhomogeneity in patients with cystic fibrosis. Lung clearance index (LCI) is the primary outcome

This is a cross-over intervention assessing the effect of autogenic drainage on ventilation inhomogeneity in patients with cystic fibrosis.

Electrical impedance tomography and multiple breath nitrogen washout will be performed before, immediatly after and 2h post intervention. Each participant will receive either aerosoltherapy alone or in combination with chest physiotherapy on 2 consecutive days.

Inclusion Criteria:

• Cystic fibrosis diagnosis
• FEV1 > 40%
• Able to sustain 30min of chest physiotherapy

Exclusion Criteria:

• Presence of Burkoldheria cepacia or non tuberculous mycobacteria
• Orthopedic, neuromuscular or cardiac disorder likely to impact respiratory system
• Need for supplemental oxygen
• Cardiac pacemaker or internal cardiac defibrillator