The study employs a double-blind, randomized clinical trial design with 50 patients diagnosed with subdeltoid bursitis. Participants are divided into two groups: with either cross-linked hyaluronic acid or non-crossed-linked hyaluronic acid injection. All injections are guided by ultrasound. Assessments are conducted before treatment and at 1 week, 1 month, and 3 months post-treatment.
Inclusion Criteria:
Unilateral shoulder pain within the past 2 weeks Pain during joint movements such as abduction or internal rotation At least one positive result from the following tests: Painful arc, Neer test, or Hawkins test No shoulder injections received in the past 3 months
Willingness to receive injection treatment and undergo follow-up assessments at the following time points:
Immediate (1 week after injection) Short-term (1 month after injection) Mid-term (3 months after injection)
Avoid use of anti-inflammatory painkillers during the study period as much as possible; if intolerable pain occurs, acetaminophen (provided by the researcher) will be used to relieve symptoms
Exclusion Criteria:
Presence of infectious disease, inflammation, rheumatoid arthritis, or fracture History of malignancy Previous shoulder surgery Sensory deficits Tendon rupture of the rotator cuff or biceps tendon Neurological disorders causing hand weakness or affecting shoulder mobility (e.g., stroke, Parkinson's disease, brachial plexus injury, peripheral neuropathy) Cognitive impairment preventing completion of questionnaires Cervical radiculopathy Diagnosed frozen shoulder (adhesive capsulitis) Psychiatric disorders Breastfeeding or pregnant women Received shoulder injection within the past 3 months, including corticosteroids, hyaluronic acid, Platelet-rich plasma, or any prolotherapy solution
M001052@ms.skh.org.tw886 + 2-28332211 ext. 2538, 2531
cross-linked acid injection
non-cross-linked hyaluronic acid injection
Effect of Different Hyaluronic Acids in the Treatment of Subdeltoid Bursitis
Cross-linked and Non-cross-linked Hyaluronic Acid in Subdeltoid Bursitis
Additional Effect of Steroid on Hyaluronic Acid in Subdeltoid Bursitis
Effect of Ultrasound-guided Hyaluronic or Corticosteroid Injections in Patients With Chronic Subacromial Bursitis
Effects of Ultrasound-guide Hypertonic Dextrose Injection for Chronic Subacromial Bursitis
Hyaluronic Acid in Shoulder Tendinopathy
Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis
Sodium Hyaluronate Injection and Corticosteroids in Trochanteric Bursitis: a Randomized Controlled Study.