Cross-linked and Non-cross-linked Hyaluronic Acid in Subdeltoid Bursitis

Comparing the Efficacy of Cross-Linked and Non-Cross-Linked Hyaluronic Acid in Treating Subdeltoid Bursitis: A Double-Blind, Randomized Clinical Trial

This study aims to compare the efficacy of different structures of hyaluronic acid, namely cross-linked and non-cross-linked hyaluronic acid, in treating subdeltoid bursitis.

A double-blind, randomized clinical trial will be conducted to collect 52 patients with subdeltoid bursitis. The patients will be injected with cross-linked or non-cross-linked hyaluronic acid under ultrasound guidance. Before treatment, one week after treatment (i.e., one week after injection), one month after treatment, and three months after treatment to detect shoulder pain (visual analog scale; pressure ergometer to measure pain pressure threshold), function (including Disabilities of the Arm, Shoulder, and Hand: DASH and Shoulder Pain and Disability Index: SPADI), quality of life (Brief version of the World Health Organization Quality of Life Scale: WHOQOL-BREF) will be arranged.

Inclusion Criteria:

• clinical diagnosis of subdeltoid bursitis
• age 20 or older 20
• at least one positive in the painful arc, neer test, or Hawkins test
• can attend three months of intervention and follow-up

Exclusion Criteria:

• history of malignancy
• previous shoulder operation or injury
• previous shoulder injections in the past three months