Coronary heart disease occurs when the blood vessels that supply the heart become narrowed or blocked. It is a leading cause of illness and death in the UK. Accurate diagnosis is important because effective treatments are available, but current tests are invasive, uncomfortable, and carry some risks.
Cardiovascular magnetic resonance (CMR), also known as a heart MRI scan, is a safe and accurate test for diagnosing coronary heart disease. However, access to CMR is limited because standard scans take around 45 to 50 minutes, restricting the number of patients who can be scanned.
Researchers have developed a faster CMR scan that takes only 15 to 20 minutes. Previous studies suggest that this shorter scan provides similar accuracy to the standard scan while improving patient comfort.
This study will recruit 2022 adults with suspected coronary heart disease from hospitals in the UK. Participants will be randomly assigned to receive either the standard CMR scan or the faster CMR scan.
The study will compare whether the accelerated scan provides similar clinical outcomes to the standard scan and whether patients prefer it. If successful, the accelerated scan could increase access to CMR by allowing more patients to be scanned each day, and enabling more efficient use of NHS resources.
Inclusion criteria
patients >18 years of age referred for routine clinical stress CMR:
A) with chest pain or angina equivalent OR
o B) with heart failure/suspected heart failure and referred for diagnosis of suspected CAD or evaluation of heart failure aetiology
Willing and able to consent to participate in the trial
Exclusion criteria
standard exclusion criteria for clinical stress CMR i.e.:
previous invasive coronary angiography (within 12 months) with normal angiographic assessment and referred for CMR diagnosis of CMD
accelerate@leicester.ac.uk+447763941607
Participants randomised to the standard care arm will undergo a standard stress cardiovascular magnetic resonance (CMR) scan
Participants randomised to the accelerated arm will undergo an accelerated stress cardiovascular magnetic resonance (CMR) scan.
Accelerated Stress CMR in Coronary Artery Disease
Accelerated Contrast-Enhanced High Resolution Whole Heart Cardiac MRI
Advanced Cardiac Magnetic Resonance Imaging for Assessment of Obstructive Coronary Artery Disease: ADVOCATE-CMR
CMR in the Assessment of Patient With ACS in the Emergency Room
iNav-based, Automated Coronary Magnetic Resonance Angiography for the Detection of Coronary Artery Stenosis
Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease-2
Non-invasive Diagnosis of Coronary Microvascular Disease: Pilot Study
Myocardial Ischemia Detection With a Combined Cardiovascular Magnetic Resonance and Biomarker Protocol