Cardiovascular Autonomic Function After Resistance Training | NCT07725952

NCT07725952

Overview

NCT ID: NCT07725952
Lead Sponsor: Pusan National University Yangsan HospitalOTHER
Official Title: Effects of 8-Week Resistance Training on Cardiovascular Autonomic Function in Spinal Cord Injury
Brief Summary: The purpose of this clinical trial is to evaluate whether an 8-week upper-limb resistance training program improves cardiovascular autonomic function in adults with chronic spinal cord injury (SCI). The primary objectives are to determine whether upper-limb resistance training improves heart rate variability (HRV) and baroreflex sensitivity (BRS), and whether it improves blood pressure responses during postural change, upper-limb strength, symptoms related to orthostatic hypotension, and quality of life.

Participants will be randomly assigned to either the resistance training group or the control group. All participants will complete assessments before and after the 8-week study period, including measurements of HRV, BRS, blood pressure responses during a tilt-table test, hand grip strength, and questionnaires assessing orthostatic hypotension symptoms and quality of life. Participants assigned to the resistance training group will participate in supervised upper-limb resistance training three times per week for 8 weeks.

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Provided written informed consent and agreed to participate in the study.

Adults aged 19 to 85 years.

Chronic spinal cord injury (SCI) of traumatic or non-traumatic etiology, at least 6 months after injury.

Cervical or thoracic spinal cord injury.

Classified as American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade A, B, C, or D.

Sufficient upper-limb range of motion to perform resistance training.

Elbow extensor muscle strength of Manual Muscle Test (MMT) grade 3 or higher.

Exclusion Criteria:

Presence of any serious medical condition that would preclude participation in the study.

Inability to understand or perform the exercise program.

Uncontrolled diabetes mellitus or progressive neurological disease.

Uncontrolled hypertension (systolic blood pressure >140 mmHg or diastolic blood pressure >90 mmHg).

History of cardiovascular disease within the past 6 months.

Current use of medications that may affect heart rate variability (HRV) or baroreflex sensitivity (BRS).

Severe orthostatic hypotension (OH) or autonomic dysreflexia (AD).

Considered unsuitable for participation in the study by a board-certified specialist in Physical and Rehabilitation Medicine.