Intermittent Ephedrine Boluses for Prophylaxis Against Postinduction Hypotension | NCT07722013

NCT07722013

Overview

NCT ID: NCT07722013
Lead Sponsor: Cairo UniversityOTHER
Official Title: Intermittent Ephedrine Boluses for Prophylaxis Against Postinduction Hypotension in High-risk Patients Undergoing Major Abdominal Surgery: a Randomized Double-blinded Controlled Trial: a Randomized Double-blinded Controlled Trial
Brief Summary: The aim of this work is to assess the efficacy of intermittent ephedrine boluses in prophylaxis against postinduction hypotension in high-risk patients undergoing major abdominal surgery, compared to standard care.
Conditions: Postinduction Hypotension
Interventions: Normal Saline
Ephedrine

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Adult patients aged >50 years,

weight >50 kg,

American Society of Anesthesiologists (ASA) Physical Status score of > I,

undergoing major abdominal surgery

Exclusion Criteria:

Severe cardiac morbidities (impaired contractility with ejection fraction < 40%, heart block, significant uncontrolled arrhythmias, tight stenotic valvular lesions)

Acute cardiovascular pathologies: acute/decompensated heart failure, acute coronary syndrome

Uncontrolled hypertension (systolic blood pressure>150 mmHg)

Preoperative HR more than 110 bpm despite proper fluid management and patients with renal impairment

Renal impairment

Patients on vasopressor infusion,

Allergy of any of the study drugs

Central Contacts: Maha Mostafa, MDContact
maha.mostafa@cu.edu.eg+201000365115