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The goal of this clinical trial is to determine the ED50 and ED95 of prophylactic norepinephrine infusion for preventing post-induction hypotension in elderly patients undergoing major abdominal surgery using up-and-down sequential method . The main question it aims to answer is:
What is the effective concentration of prophylactic norepinephrine infusion for preventing post-induction hypotension in elderly patients.
Participants will receive different concentrations of norepinephrine infusion at the beginning of anesthesia induction until 15 minutes after intubation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Norepinephrine | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| norepinephrine bitartrate | Drug | The treatment group will receive a continuous infusion of norepinephrine at the beginning of anesthesia induction until 15 minutes after intubation. The dosage of norepinephrine was decided by the up-and-down sequential allocation method with an initial dose of 0.05 µg/kg/min and a 0.005 µg/kg/min gradient. |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of hypotension | less than 80% baseline blood pressure less than 80% baseline blood pressure less than 80% baseline blood pressure | 15 minutes after intubation |
| Measure | Description | Time Frame |
|---|---|---|
| incidence of bradycardia | heart rate less than 50 beat per minute | 15 minutes after intubation |
| incidence of reactive hypertension | increased mean arterial pressure by > 20% of the baseline reading |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Min Yan, Doctor | Contact | 13757118632 | zryanmin@zju.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Second Affiliated Hospital of Zhejiang University Medical College | Recruiting | Hangzhou | Zhejiang | 310000 | China |
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|
| 15 minutes after intubation |
| ID | Term |
|---|---|
| D009638 | Norepinephrine |
| ID | Term |
|---|---|
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D000588 | Amines |
| D015306 | Biogenic Monoamines |
| D001679 | Biogenic Amines |
| D002395 | Catecholamines |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
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