Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial function. investigators emulated a target trial to evaluate whether early perioperative L-arginine was associated with a lower risk of AKI after cardiac surgery.
Inclusion Criteria:
·adults admitted to the ICU after CPB-assisted cardiac surgery
Exclusion Criteria:
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Initiation of L-arginine within 3 postoperative days
No L-arginine therapy within 3 postoperative days
Association Between Postoperative Administration of L-Arginine and CSA-AKI
Intravenous Amino Acid Therapy for Kidney Protection in Cardiac Surgery.
Amino Acids for Cardiac Surgery Associated AKI
Perioperative Use of NAC to Prevent AKI in Patients With Pre-existing Moderate Renal Insufficiency Following Cardiac Surgery
L-arginine for Prevention of Kidney Damage in Liver Transplant Recipients
Early Versus Late Renal Replacement Therapy After Cardiac Surgery
Early RRT in AKI After Cardiac Surgery
Perioperative Use of Amino Acids in Recipients of Orthotopic Liver Transplantation as a Renal Protective Factor