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NCT07717255

Overview

NCT ID: NCT07717255
Lead Sponsor: East and North Hertfordshire NHS TrustOTHER_GOV
Official Title: Adequacy of Haemodiafiltration: Middle Molecules Clearance, Patients Reported Outcomes and Sodium Balance
Brief Summary: The goal of this observational study is to understand the differences in terms of middle molecules clearance and patient outcomes in High (>23Litres (L)) vs Low (<23 L) convection volume (CV) Hemodiafiltration (HDF) and to understand the effect of dialysate fluid sodium concentration (137 vs 140 mmol/L) on overhydration volume in patients on HD and HDF.
Conditions: Haemodiafiltration
Haemodialysis
Patient Reported Outcome Measurements
Nutrition
Malnutrition (Calorie)
Fluid Balance Outcomes

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Age 18 years or above.

Ability to give informed consent.

End stage kidney disease (ESKD) treated by haemodialysis for at least 3 months.

Prognosis > 6 months as assessed by principal investigator (PI)

Central Contacts: Usama Afzal Butt, MBBS, MRCP (UK)Contact
usama.butt1@nhs.net+441438284340

Participant Group/Arms

HDF group

Particiapants receiving hemodiafiltration

HD group

Participants receiving high flux hemodialysis

Low dialysate sodium group

Participants dialysing with dialysate sodium concentration 137 mmol/L

High dialysate sodium group

Participants dialysing with dialysate sodium concentration 137 mmol/L