To Assess the Effect of HDF Versus High Flux Dialysis on Free Light Chains and Cumulative Albumin Loss, in End Stage Renal Disease Patients.

The Effect of Hemodiafiltration Versus High Flux Dialysis On Free Light Chains Reduction And Its Relation To Albumin Loss.

Removal of uremic toxins is the main goal of HD, It was improved by using high volume convective technique with high flux (HF) dialyzer. This technique removes medium - large molecular weight solutes giving higher dialysis adequacy and consequently improving the quality of life.

This study will assess the effect of hemodiafiltration (HDF) versus high flux dialysis on free light chains (FLC) reduction as a marker of HD adequacy and its relation to albumin loss using dialyzer effective surface area 2.6m2.

Inclusion Criteria:

• Prevalent HD patients on regular hemodialysis sessions for >6 months 3 sessions/week of 4 hours duration.
• Patients with Arterio-venous fistula as dialysis access.

Exclusion Criteria:

• Patients with hemodialysis catheters.
• Patients with active inflammation or infection.
• Decompensated heart failure.
• Liver Cell Failure ( Child B,C)
• Patients with known malignancies.