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NCT07715188

Overview

NCT ID: NCT07715188
Lead Sponsor: Abramson Cancer Center at Penn MedicineOTHER
Official Title: A Prospective Study of Low Dose Radiotherapy for Osteoarthritis
Brief Summary: This single institution, multi-site, single arm prospective study will enroll patients with a history of OA and assess changes in pain and function after treatment with LDRT as measured by patient-reported outcomes.
Conditions: Osteoarthitis
Interventions: Low Dose Radiation Therapy

Status and Timeline

Status: Recruiting
Last Update Posted: Jul 20, 2026Actual
Start Date: Jun 24, 2026Actual
Primary Completion Date: Jun 2029Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

18 years or older

Diagnosis of OA >3 months in hips, knees, hands, shoulders, ankles or elbows.

Refractory to standard of care therapies for OA or those who are being considered for more aggressive interventional treatment such as joint replacement, but more conservative treatment is desired.

Provision of signed and dated informed consent.

Exclusion Criteria:

Unable to reasonably complete study instruments.

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 113Estimated
Primary Purpose: Treatment
Allocation: N/A
Interventional Model: Single Group Assignment
Masking: None (Open Label)

Contacts and Locations

Central Contacts: Marlowe Estioko, BS, MSContact
Marlowe.Estioko@Pennmedicine.upenn.edu

Similar Studies

Participant Group/Arms

SingleOther

Participants will complete study intervention which consists of the BPI-SF, PROMIS Global v1.2, UEFI (for those with joint pain of the upper extremity) and/or LEFS (for those joint pain of the lower extremity) at baseline, 3-month and 1-year follow-up following 1 or 2 courses of standard of care LDRT.

Radiation: Low Dose Radiation Therapy

Locations

Penn Presbyterian Medical CenterRecruiting

Philadelphia, Pennsylvania 19104, United States

Marlowe Estioko, BS, MSContact

Marlowe.Estioko@Pennmedicine.upenn.edu267-343-6483

Sonya George, BSContact

Sonya.George@PennMedicine.upenn.edu267-760-7636

John Plastaras, MD, PhDPrincipal Investigator

Perelman Center for Advanced MedicineRecruiting

Philadelphia, Pennsylvania 19104, United States