Subjects will receive a total of six (6) low-dose radiotherapy (LDRT) treatments for hand osteoarthritis.

Subjects will receive standard of care corticosteroid injection (CSI) therapy for hand osteoarthritis.

A maximum of 3 joints will be treated with standard a standard combination of methylprednisolone and lidocaine:

• 1st Carpometacarpal (CMC) joint - 20 mg methylprednisolone/0.5 mL 1% lidocaine*
• Radiocarpal (RC) joint - 40 mg methylprednisolone/1 mL 1% lidocaine*
• Scaphotrapeziotrapezoidal (STT) joint - 20 mg methylprednisolone/0.5 mL 1% lidocaine*
• Metacarpophalangeal (MCP) joint - 20 mg methylprednisolone/0.5 mL 1% lidocaine
• Interphalangeal (IP) joint - 10 mg methylprednisolone/0.25 mL 1% lidocaine

Pain values reported by participants will be assessed using the 100-mm Visual Analogue Scale (VAS). The VAS line will be 100 mm long with no intermediate delineations. Each end will be marked with "no pain" on the left, and "worst possible pain" on the right. Participants will identify their pain level by indicating a point on the line between each end. That point will be measured from the "No pain" end, and the number of millimeters will be reported as the pain score.

The Cochin Hand Function Scale (CHFS) uses an 18-item, 5-point Likert scale (0 to 5) for scoring, where higher scores indicate greater difficulty with hand function. Scores range from 0 (no difficulty) to 90 (impossible to complete) by summing the ratings for all 18 items. This scale measures the ability to perform daily activities related to the hand, such as kitchen tasks, dressing, and hygiene.