Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| National Dairy Council | OTHER |
Not provided
Not provided
Not provided
Not provided
The study will examine the impact of adding two servings per day of skimmed or whole milk Greek yogurt on integrated muscle protein synthesis (iMPS), blood sugar control, and cognition in post-menopausal women with overweight and obesity.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Skimmed Milk Greek Yogurt | Active Comparator | Participants will consume two servings per day of skimmed milk Greek yogurt. |
|
| Whole Milk Greek Yogurt | Active Comparator | Participants will consume two servings per day of whole milk Greek yogurt. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Skimmed vs Whole Milk Greek Yogurt | Other | Participants will be randomized to receive a standardized diet with either skimmed milk or whole milk Greek yogurt. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Integrated Muscle Protein Synthesis (iMPS) | Integrated muscle protein synthesis expressed as the fractional synthetic rate (%/day). | 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose Homeostasis | Mean glucose and mean amplitude of glucose excursions (MAGE) as determined from continuous glucose monitors (CGMs) (mg/dL). | 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma Essential Amino Acids (EAAs) | Postprandial plasma EAA concentrations (µmol/L) in response to skimmed and whole milk Greek yogurt intake. | Baseline to 30, 60, 90, 120, 150, 180, 210, and 240 minutes post yogurt ingestion |
| Cognition: Reaction Time, Alertness, and Selective Attention |
Inclusion Criteria:
Aged 50 to 65 years
Body mass index ≥25 to <40 kg/m2 or body fat ≥36%
Able to provide informed consent
Absence of menstruation for ≥12 months without the use of hormonal contraceptives, or one of the following:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| David D. Church, PhD | Contact | 501-526-5769 | dchurch@uams.edu | |
| Joseph J Matthews, PhD | Contact | 501-526-5707 | jmatthews@uams.edu |
| Name | Affiliation | Role |
|---|---|---|
| David D Church, PhD | University of Arkansas | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | United States |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Determined from simple and choice reaction (reaction time and alertness) and the Stroop test (selective attention) (milliseconds; ms). |
| Baseline to 1- and 4-hours post yogurt ingestion |
| Cognition: Updating | Determined from the 2-back test (discriminatory ot targets; d'). | Baseline to 1- and 4-hours post yogurt ingestion |
| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided