Collagenase Injection for Spasticity Management

Collagenase Injection for Contracture and Spasticity Management

The overall goal is to investigate the effectiveness of a novel intervention - Collagenase injection, for spasticity management in patients with neurological impairments, such as stroke, brain injury, and spinal cord injury.

Inclusion Criteria:

• ≥ 6 months post stroke, brain injury or spinal cord injury, medically stable;
• MAS ≥ 1

Exclusion Criteria:

• Is hypersensitive to XIAFLEX or collagenase;
• Is currently adjusting tone alternating medications (e.g., baclofen), or
• Received botulinum toxin injection to target areas <4 months, or phenol injections < 9 months;
• Received surgical release of tendons;
• Is a pregnant woman;
• Has coagulation disorders, including those who receive concomitant anticoagulants (except for low-dose aspirin).
• has heritable connective tissue disorders, including those within the Ehlers-Danlos syndrome (EDS) spectrum.