Collagenase in the Treatment of Adhesive Capsulitis (Frozen Shoulder)

Collagenase in the Treatment of Adhesive Capsulitis (Frozen Shoulder)

The purpose of this study is to test collagenase injection therapy to dissolve adhesions causing frozen shoulder.

In a random, placebo controlled, double blind study, collagenase injection therapy will be investigated for it's ability to lyse the adhesions associated with the shoulder capsule in adhesive capsulitis (frozen shoulder).

Treatment success may obviate the need for extensive physical therapy and/or shoulder arthroscopy (surgery) to correct this condition and restore normal and pain free shoulder motion.

Inclusion Criteria:

• diagnosis of frozen shoulder of at least one month duration

Exclusion Criteria:

• shoulder arthritis
• rotator cuff tears
• any chronic, serious, uncontrolled medical condition
• inability to conform to study visits (20-30 per year)