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| ID | Type | Description | Link |
|---|---|---|---|
| R01MH132792 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Mental Health (NIMH) | NIH |
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The goal of this clinical trial is to examine whether food value construction can be biased in individuals with anorexia nervosa. The main question it aims to answer is:
Can a simple training task increase the importance of relevant food attributes such that subsequent choices about what to eat in individuals with anorexia nervosa will look more like those of healthy eaters?
Participants will undergo a simple training paradigm where they view food items and focus on different attributes (e.g., its tastiness or healthiness). Participants will then be asked to make decisions about what foods they'd like to eat.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anorexia Nervosa | Experimental | Participants in this group will meet diagnostic criteria for anorexia nervosa. |
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| Healthy Control | Experimental | Participants in this group will not meet diagnostic criteria for any psychiatric illness. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Training food attributes | Behavioral | Participants will view images of foods and asked to focus on different attributes of the food (e.g., its healthiness or tastiness) |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Decision Weight for Tastiness vs. Healthiness Attributes in Food Choice | Food choice will be assessed using a binary choice task in which participants choose between pairs of food items that vary on healthiness, tastiness, savoriness, and overall preference. Choice data will be modeled using mixed-effects logistic regression, with delta-healthiness (difference in healthiness rating between paired items) and delta-tastiness (difference in tastiness rating) entered as predictors of choice. The parameter of interest is the regression coefficient (beta weight) for delta-tastiness relative to delta-healthiness, reflecting the degree to which choice is driven by tastiness versus healthiness attributes. We predict that tastiness beta weight will increase pre- to post-training in patients with AN. | Immediately prior to and immediately following the training session (pre- and post-assessments, approximately 1 hour apart on the same day) |
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Inclusion Criteria:
Exclusion Criteria for all participants:
Exclusion Criteria for participants with anorexia nervosa:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Akram Bakkour | Contact | 773-702-9574 | bakkour@uchicago.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Chicago | Chicago | Illinois | 60637 | United States |
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| ID | Term |
|---|---|
| D000856 | Anorexia Nervosa |
| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| D001523 | Mental Disorders |
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