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| ID | Type | Description | Link |
|---|---|---|---|
| ANSM | Other Identifier | 2024-A02435-42 |
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Lipid restriction is significant in anorexia nervosa and limits therapeutic management. The multisensory perception of fat is altered, creating an aversion to lipids. The investigators aim to characterize the impact of sensory stimulation (smells or images) associated with specific tastes using neuropsychological assessments and functional MRI. Some volatile aromas can enhance the perception of the associated taste. The investigators hypothesize that such associations are altered in anorexia nervosa for fatty foods but may be preserved for sweet tastes, and that this alteration contributes to the maintenance of the disease. The interdependence of different sensory perceptions of lipids could play a major role in the therapeutic approach, aiding in the deconditioning of this aversion and the restoration of positive food sensory associations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anorexia Nervosa patient group | Experimental | 30 patients with anorexia nervosa |
|
| Normal Weight Control group | Active Comparator | 30 control subjects of normal weight |
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| Low Weight Control group | Active Comparator | 30 control subjects with a similar weight to AN patients (the constitutional thinness group) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI examination | Other | One hour MRI examination |
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| Measure | Description | Time Frame |
|---|---|---|
| Brain activity measured by functional MRI | Estimation of the "fatty vs. neutral" contrast when all three senses are used, comparing AN patients to the normal-weight control group (NC group) in each voxel of the brain volume (whole-brain analysis) and in the orbitofrontal cortex (ROI analysis). | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Brain activity measured by functional MRI | Estimation of the "fatty vs. neutral" contrast when all three senses are used, comparing AN patients to the control group with a similar BMI (CT group) in each voxel of the brain volume (whole-brain analysis) and in the orbitofrontal cortex (ROI analysis). | Day 1 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fabien SCHNEIDER, MD | Contact | (0)477127529 | +33 | fabien.schneider@univ-st-etienne.fr |
| Florence RANCON, CDP | Contact | (0)477829458 | +33 | florenc.rancon@chu-st-etienne.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Saint-Etienne | Saint-Etienne | 42055 | France |
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| ID | Term |
|---|---|
| D000856 | Anorexia Nervosa |
| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D012903 | Smell |
| ID | Term |
|---|---|
| D012677 | Sensation |
| D009424 | Nervous System Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Smell and taste capacity testings | Other | one hour sensory testings |
|
| Brain activity measured by functional MRI |
BOLD signal variations between the groups (AN, NC, and CT) for the "sweet vs. neutral" contrast. |
| Day 1 |
| Brain activity measured by functional MRI | BOLD signal variations for single vs. three senses simultaneously for each group and between groups for the "fatty vs. neutral" and "sweet vs. neutral" contrasts. | Day 1 |
| BMI | Body Mass Index | DAY 1. |
| Olfactory and gustatory abilities | MediSens tests of olfactory and gustatory abilities | Day 1 |
| 3DT1 morphological MRI | Brain morphometric measures and voxel-based morphometry. | Day 1 |