Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| EKK25-26/15/08 | Other Identifier | Cyprus International University Ethics Review Board |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide and is associated with several cancers. Adequate knowledge about HPV and vaccination remains limited among university students. This randomized controlled trial aims to evaluate the effectiveness of an artificial intelligence (AI) chatbot-based educational program in improving HPV knowledge among undergraduate nursing students at Cyprus International University. Participants will be randomly assigned to either an AI chatbot-based personalized education group or a control group receiving standard written educational materials. HPV knowledge will be assessed before and after the intervention using the validated HPV Knowledge Questionnaire. The findings will provide evidence regarding the effectiveness of AI-supported educational strategies for improving HPV-related knowledge among university students
Study Purpose
The purpose of this study was to evaluate the effectiveness of an AI chatbot-based educational program in improving Human Papillomavirus (HPV) knowledge among undergraduate nursing students.
Study Design
This study was designed as a parallel-group randomized controlled trial conducted among undergraduate nursing students at Cyprus International University, Northern Cyprus. Participants were randomly assigned to either the intervention group (AI chatbot-based personalized education) or the control group (standard written educational materials) using block randomization.
Sample Size
Based on a previous educational intervention study and the two-sample mean comparison formula, with a significance level of 0.05 and a statistical power of 80%, the required sample size was calculated as 30 participants per group. After allowing for a 10% dropout rate, a total of 68 participants were enrolled, with 34 participants allocated to each study group.
Data Collection Tools
Data were collected using:
A demographic questionnaire (age, gender, faculty, year of study, previous HPV education, source of HPV information, and HPV vaccination status).
The validated 29-item HPV Knowledge Questionnaire developed , assessing general HPV knowledge, HPV testing knowledge, and HPV vaccination knowledge.
Intervention
Participants were randomly assigned to one of two groups.
AI Chatbot Group:
Participants received personalized HPV education through an artificial intelligence (AI) chatbot. Educational content was tailored according to each participant's baseline HPV knowledge and included information on HPV transmission, risk factors, HPV-related diseases, vaccination, prevention strategies, and common misconceptions.
Control Group:
Participants received standard written educational materials covering the same HPV-related topics without chatbot interaction or personalized educational content.
Outcome Assessment
HPV knowledge was measured before and after the educational intervention using the validated HPV Knowledge Questionnaire.
Ethical Considerations
The study received approval from the Cyprus International University Ethics Review Board (Approval No. EKK25-26/15/08). The study was conducted in accordance with the Declaration of Helsinki, and written informed consent was obtained from all participants before enrollment.
Statistical Analysis
Data will be analyzed using SPSS version 26. Descriptive statistics, independent t-tests, paired t-tests, Chi-square tests, Fisher's exact tests, and non-parametric tests will be performed as appropriate. Statistical significance will be be set at a two-sided P value of less than 0.05.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AI Chatbot-Based Education | Experimental | Participants in this group received personalized education about Human Papillomavirus (HPV) through an artificial intelligence (AI) chatbot. The educational content was tailored according to each participant's baseline HPV knowledge and covered HPV transmission, risk factors, HPV-related diseases, HPV vaccination, prevention strategies, and common misconceptions |
|
| Standard Written Education | Active Comparator | Participants in this group received standard written educational materials covering the same HPV-related topics, including HPV transmission, risk factors, HPV-related diseases, HPV vaccination, and prevention strategies. No personalized feedback or AI chatbot interaction was provided |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AI Chatbot-Based Education | Behavioral | Participants received personalized education through an artificial intelligence (AI) chatbot. Educational content was tailored according to each participant's baseline HPV knowledge and included information on HPV transmission, risk factors, HPV-related diseases, HPV vaccination, prevention strategies, and common misconceptions. The chatbot provided interactive, personalized educational support throughout the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| HPV Knowledge Score | The primary outcome measure assesses changes in participants' knowledge of Human Papillomavirus (HPV) following the educational intervention. HPV knowledge is measured using the validated 29-item HPV Knowledge Questionnaire developed by Waller et al. (2013). The questionnaire evaluates three domains: general HPV knowledge, HPV testing knowledge, and HPV vaccination knowledge. Higher total scores indicate greater HPV-related knowledge | Baseline (before the educational intervention) and 1 month after completion of the educational intervention. |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Pouran Varvani Farahani, PhD | PhD in Pediatric Nursing, Department of Nursing, Faculty of Health Science, Cyprus International University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pouran Varvani Farahani | Nicosia | North Cyprus | Cyprus |
No There is no plan to make IPD available to other researchers
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D006266 | Health Education |
| ID | Term |
|---|---|
| D000099060 | Adherence Interventions |
| D055118 | Medication Adherence |
| D010349 | Patient Compliance |
| D010342 | Patient Acceptance of Health Care |
Not provided
Not provided
Participants were randomly assigned to one of two groups: an AI chatbot-based personalized education group and a control group receiving standard written educational materials. Both interventions were designed to improve knowledge of Human Papillomavirus (HPV), HPV-related diseases, and HPV vaccination. HPV knowledge was assessed before and after the educational intervention using the validated HPV Knowledge Questionnaire to evaluate the effectiveness of the AI chatbot-based educational program.
Not provided
Not provided
To reduce bias, the statistician responsible for data analysis remained blinded to group allocation. Group assignments were coded as Group A and Group B during statistical analysis.
|
| Standard Written Education | Behavioral | Participants received standard written educational materials covering HPV transmission, risk factors, HPV-related diseases, HPV vaccination, and prevention strategies. The educational materials were identical in content to the intervention group but were provided without personalization or AI chatbot interaction |
|
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |
| D001519 | Behavior |